A method for predicting the active sites of protein tyrosine phosphotases based on protein surface patches

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Title:	A method for predicting the active sites of protein tyrosine phosphotases based on protein surface patches
Authors:	張慧玫 Chang, Whei-meih
Contributors:	生物資訊學系 Bioinformatics
Keywords:	雙特異性磷酸水解酶;活化部位;α-ball蛋白質表面結構模型 protein tyrosine phosphatases;dual-specificity phosphatases;active site;α-ball protein surface structure modeling
Date:	2010
Issue Date:	2014-06-27 01:06:03 (UTC+8)
Abstract:	摘要蛋白質為執行生物體生理現象與催化機能最主要的大分子。藉由蛋白質交互作用的調控，細胞訊息在傳遞路徑中進出而產生不同的反應。細胞訊息傳遞路徑中，必須即時切換蛋白質活性，其中以對參與反應的蛋白質作磷酸化或磷酸水解是常見且關鍵的調節作用。本研究主要是表面結構模型程式預測酪胺酸磷酸水解酶(protein tyrosine phosphatases, PTPs)蛋白質家族的活化部位。訓練組數據取自PTPs家族的子分類蛋白質群，即雙特異性磷酸水解酶 (dual-specific protein phosphat Proteins are main macro-molecules to operate the physical activities and catalytic functions in organisms. Proteins interacting with other proteins regulate the flows and various responses of biological signal transduction pathways. To ensure timing-switc
Appears in Collections:	[Department of Bioinformatics] Journal Articles

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